7-Amino-3-cephem-4-carboxylic acid
Basic Information:
English alias:
7-ANCA;7-AMOCA;(6R,7R)-7-AMino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicAcid;7-NACA;7-NACA、7-ANCA;7-ANCAChemicalbookimpurity;CeftizoximeImpurity9;CeftizoximeImpurity16;Ceftizoximeintermediate(7-anca);7-amino-3-cephem-4-carboxylicacid
CAS number: 36923-17-8
Molecular formula: C7H8N2O3S
Molecular weight: 200.21
EINECS number: 609-312-7
Structural formula:
Related categories: Organic intermediates; Pharmaceutical intermediates; Pharmaceutical raw materials.
Melting point: 215-218°C
Boiling point: 536.9±50.0 °C(Predicted)
Density: 1.69± 0.1g /cm3(Predicted)
Refractive index: 1.735 (estimate)
Flash point: 278.508°C
Solubility: Soluble in acidic aqueous solution (slight, heated), DMSO (slight). Properties: White or white crystalline powder.
Vapor pressure: 0mmHg at 25°C
| specification | unit | standard |
| Appearance | White or white crystalline powder | |
| Main content | % | ≥98.5% |
| Moisture | % | ≤1 |
| Mono hybrid | % | ≤0.5 |
| Total clutter | % | ≤1 |
Cephalosporin, used as an intermediate of cefbutan and cefazoxime.
Concentrated sulfuric acid (104.3mL, 1.92mol) was added into three bottles, then isophthalic acid (40g, 0.24mol) was added, stirred and heated to 60℃, held for 0.5h, and 60% nitric acid (37.8g, 0.36mol) was added to control the droplet acceleration degree. Add it in 2 hours. After addition, heat preservation reaction at 60℃ for 2 hours. Cool to below 50 ° C, then add 100mL of water. The material was cooled to room temperature, poured into the filter, pumped to remove the waste acid, the filter cake was washed with water, drained to recrystallize, and the white product was 34.6 grams, the yield was 68.4%.
20Kg or 25Kg/ bucket, cardboard bucket, lined with a white layer and a black polyethylene bag. 2℃-8℃ dry, cool place, away from light storage, valid for 2 years.
