2-methyl-5-nitroimidazole
Basic Information:
Chemical name: 2-methyl-5-nitroimidazole;
English name: 2-Methyl-5-nitroimidazole;
CAS number: 88054-22-2
Molecular formula: C4H5N3O2
Molecular weight: 127.1
EINECS number: 618-108-7
Structural formula:
Related categories: raw materials; Pharmaceutical intermediates; Pharmaceutical raw materials.
Density :1.4± 0.1g /cm3
Boiling point :399.5±15.0 °C at 760 mmHg
Melting point :252-254ºC
Flash point :195.4±20.4 °C
Precise mass :127.038177
PSA:74.50000 LogP:-0.10
Appearance: White crystal
Vapor pressure :0.0±0.9 mmHg at 25°C
Refractive index :1.592
Storage conditions: sealed in a cool and dry environment of 0-6 ºC
Stability: it will not decompose when used and stored according to regulations.
| specification | unit | standard |
| Appearance | Like white or yellowish powder | |
| Content | % | ≥99% |
| Moisture | % | ≤0.3 |
| Sulphate | % | ≤0.3 |
Mainly used in the synthesis of metronidazole, dimetazole and other drugs intermediates.
It is obtained by nitration of 2-methylimidazole. Put sulfuric acid, 2-methylimidazole and sodium sulfate into the reaction pot, stir and heat, add nitric acid at 150-160℃, add up, follow the casket reaction for 1 hour. Remove the temperature to 140℃ below, after adding water with ammonia water to adjust the pH to 3.5-4, crystallization. Strain, wash to neutral, dry, 2-methyl-5-nitroimidazole.
25k kraft paper bag or woven bag (58×110) lined with plastic bag, 250kg export container bag (100×80); According to customer requirements;
Sealed storage, stored in a cool, dark, dry warehouse, storage and transportation should be light, to prevent damage and moisture, strictly prohibited with drugs mixed.
Production method: Obtained by nitration of 2-methylimidazole. Put sulfuric acid, 2-methylimidazole and sodium sulfate into the reaction pot, stir and heat, add nitric acid at 150-160℃, add up, follow the casket reaction for 1 hour. Remove the temperature to 140℃ below, after adding water with ammonia water to adjust the pH to 3.5-4, crystallization. Strain, wash to neutral, dry, 2-methyl-5-nitroimidazole.
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