2-chloro-5-chloromethyl pyridine
Basic Information:
Chemical name:2-chloro-5-chloromethyl pyridine
CAS number: 70258-18-3
Molecular formula: C6H5Cl2N
Molecular weight: 162.02
EINECS number: 615-091-8
Structural formula：
Related categories: Intermediates – pesticide intermediates; Pharmaceutical intermediates; Organic chemical raw materials and intermediates;
Melting point: 37-42 °C(lit.) Boiling point: 267.08°C (rough estimate) Density: 1.4411 (rough estimate) Refractive index: 1.6000 (estimate) Flash point: >230 °F Solubility: Soluble in DMSO (a little), methanol (a little), insoluble in water. Character: beige crystal. Acidity coefficient (pKa)-0.75±0.10(Predicted)
| specification | unit | standard |
| Appearance | Colorless to beige crystal | |
| Main content | % | ≥98.0% |
| Moisture | % | ≤0.5 |
2-chloro-5-chloromethyl pyridine (CCMP) is an important pharmaceutical intermediate and an important intermediate for the synthesis of pyridine pesticide agents such as imidacloprid, acetamiprid, fluazinam, etc.
There are many synthesis methods of 2-chloro-5-chloromethyl pyridine. At present, 2-chloro-5-methylpyridine is used as raw material in the industry, that is, 2-chloro-5-methylpyridine is chlorinated by 2-chloro-5-methylpyridine in the presence of a catalyst to obtain 2-chloro-5-chloromethyl pyridine. The 2-chloro-5-methylpyridine and solvent were added to the chlorination kettle, the catalyst was added, and chlorine gas was injected into the reaction under the reflux condition. After the reaction, the first atmospheric pressure was dissolved, and then the former fraction was removed by vacuum in the distillation kettle, and 2-chloro-5-methylpyridine was obtained from the bottom of the kettle. In addition to the , there are a variety of different routes using niacin as raw material, 3-methylpyridine as raw material, 2-chloro-5-trichloromethyl pyridine as raw material. A common feature of these methods is the formation of a pyridine ring followed by the completion of chloromethylation. Another route developed by the United States Rayleigh Company (ReillyIndustriesInc.) takes cyclopentadiene and propanal as starting raw materials to directly cyclosynthesize 2-chloro-5-chloromethyl pyridine, and the purity of the product is as high as 95%, without the isomer 2-chloro-3-chloromethyl pyridine.
25Kg/barrel; Packing according to customer's requirements.
This product should be stored in a sealed container and kept in a cool and dry place during storage and transportation. Do not mix with oxidants for transportation and storage.
